Document Type : Review Article







Background: Increased oxidative stress is a significant factor in obesity-related diseases and likely plays a fundamental role in the pathophysiology of diabetes.Aim: The purpose of this study was to investigate the effect of High-Intensity Interval Training (HIIT) on certain antioxidant biomarkers (CAT and SOD) in women with type 2 diabetes.
Materials and Methods: This clinical trial was conducted on 30 women aged 50 to 65 with type 2 diabetes. The participants were divided into two groups: experimental and control. The intervention group engaged in HIIT for 8 weeks, three sessions per week. The levels of CAT and SOD were measured by collecting 5 mL of venous blood before and after the intervention. The data were analyzed using dependent t-test in SPSS software version 25, with a significance level of p < 0.05.
Results: According to the results, after 8 weeks of intervention, in the HIIT group (p = 0.00), (mean difference = 0.540), there was a significant decrease in the variable CAT, while in the control group (p = 0.32), (mean difference = 0.390), no significant difference was observed. The data for the SOD variable indicated a significant decrease in the HIIT groups (p = 0.00), (mean difference = 9.876). However, in the control group (p = 0.67), (mean difference = 0.120), a significant difference was not observed
Conclusion: High-Intensity Interval Training with a prolonged duration leads to cellular stress and destruction of the antioxidants SOD and CAT, thus exerting negative effects on the cellular antioxidant capacity.


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